The entire massif and surrounding area are protected within the 7,629 km2 Annapurna Conservation Area, the first and largest conservation area in Nepal. The Annapurna Conservation Area is home to several world-class treks, including the Annapurna Circuit.
The Annapurna peaks are the world's most dangerous mountains to climb although, from figures since 1990, Kangchenjunga surpasses Annapurna's death rate. As of 2007, there had been 153 summit ascents of Annapurna I, and 58 climbing fatalities on the mountain. This fatality to summit ratio (38%) is the highest of any of the eight-thousanders. In particular, the ascent via the south face is considered the most difficult of all climbs.